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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRK
All Species:
15.15
Human Site:
S495
Identified Species:
27.78
UniProt:
P42685
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42685
NP_002022.1
505
58254
S495
E
D
Y
F
E
T
D
S
S
Y
S
D
A
N
N
Chimpanzee
Pan troglodytes
XP_518702
505
58217
S495
E
D
Y
F
E
T
D
S
S
Y
S
D
A
N
N
Rhesus Macaque
Macaca mulatta
XP_001112190
505
58228
S495
E
D
Y
F
E
T
D
S
S
Y
S
D
A
N
N
Dog
Lupus familis
XP_539091
505
57709
E496
W
K
F
E
D
Y
F
E
T
D
V
S
F
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q922K9
512
58825
C502
E
D
Y
F
E
T
D
C
S
Y
S
D
T
N
N
Rat
Rattus norvegicus
Q62662
506
58147
S496
E
D
Y
F
E
P
D
S
S
Y
S
D
T
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q02977
536
59984
E527
E
D
Y
F
T
A
T
E
P
Q
Y
Q
P
G
D
Frog
Xenopus laevis
P13406
537
60828
E528
E
D
Y
F
T
A
T
E
P
Q
Y
Q
P
G
D
Zebra Danio
Brachydanio rerio
XP_695937
480
54879
I469
E
D
F
F
D
M
D
I
T
S
Y
D
D
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V9J3
517
59051
Q508
E
D
F
Y
T
S
D
Q
S
D
Y
K
E
A
Q
Honey Bee
Apis mellifera
XP_396043
451
51726
G442
E
D
F
F
T
M
E
G
S
E
Y
K
E
A
S
Nematode Worm
Caenorhab. elegans
NP_493502
507
57512
S497
E
D
L
F
N
L
D
S
S
E
Y
K
E
A
S
Sea Urchin
Strong. purpuratus
NP_001135852
530
59779
G520
E
E
F
F
V
M
E
G
E
Q
Y
R
E
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
96.6
80.5
N.A.
88.6
88.3
N.A.
N.A.
48.5
48.4
60.5
N.A.
56.8
51.6
50.4
56.6
Protein Similarity:
100
99.8
98
87.7
N.A.
92.9
93
N.A.
N.A.
64.7
64.2
74
N.A.
73.3
67.1
69.4
70.5
P-Site Identity:
100
100
100
0
N.A.
86.6
86.6
N.A.
N.A.
26.6
26.6
40
N.A.
26.6
26.6
40
13.3
P-Site Similarity:
100
100
100
33.3
N.A.
86.6
86.6
N.A.
N.A.
33.3
33.3
60
N.A.
46.6
46.6
46.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
16
0
0
0
0
0
0
24
39
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
85
0
0
16
0
62
0
0
16
0
47
8
0
24
% D
% Glu:
93
8
0
8
39
0
16
24
8
16
0
0
31
0
0
% E
% Phe:
0
0
39
85
0
0
8
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
16
0
0
0
0
0
16
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
24
0
0
0
% K
% Leu:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
0
39
47
% N
% Pro:
0
0
0
0
0
8
0
0
16
0
0
0
16
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
24
0
16
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
39
62
8
39
8
0
8
24
% S
% Thr:
0
0
0
0
31
31
16
0
16
0
0
0
16
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
54
8
0
8
0
0
0
39
54
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _